Abstract:

This study was aimed at determining the levels of beta hydroxic butic acid (BHBA), vitamin B12, folate and glucose in pregnancy toxemic and cows and identifying the relationship with the disease. For this purpose, a total of 54 Halep goats were included in the study in the last 6 weeks of the estimated pregnancy, between 1-4 years of age. Clinical examinations of all goats and BHBA measurements were carried out. The bears were classified as non-ketonemic (<0.8 mmol/L, n=15), medium hyperketonemic (0.8-1.6 mmol/L, n=13) and severe hyperketonemic (>1.6 mmol/L, n=26) according to the blood values of β-hydroxibutyrate (BHBA). There is no significant difference between the non-ketonemic group in the BHBA value and the middle hyperketonemic group (P>0. There was a significant difference between the non-ketonemic group and the severe hyperketonemic group (P<0.001). The concentration of vitamin B12 was significantly identified between the three groups (P<0.005). The concentration of folate and glucose was not significant between the 3 groups (P>0.05). In the correlation chart between the variables in pregnancy toxes, a positive correlation between the BHBA concentration and vitamin B12 (r=0.392, P<0.05) and glucose (r=0.394, P<0.05) was observed. A positive correlation between vitamin B12 and folate (r=0.206, P<0.05) and glucose (r=0.323, P<0.05) was also observed. As a result, the results suggest that hyperketonemia is associated with serum B12 and glucose concentrations. Additional studies are needed to understand the mechanism below the height of B12 in goats with pregnancy toxemia.

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