Özet:

Vitamin B12, which plays a role in DNA synthesis, is necessary for blood cell maturity and the normal function of the nervous system (1). In this study, we studied the relationship between the etiological factors and the level of vitamin B12 in people with vitamin B12 deficiency and the MCV, homosysteine, folate levels and thyroid function tests. In July 2009 - September 2009, 115 patients with vitamin B12 levels below 189 (normal intervals) were included in the study in patients who were applying to the Haseki Education Research Hospital. Fe deficiency patients with anemia, talasemia, diagnosed with acute lupus were removed from the study. Patients were questioned for the age, lack of intake, use of medications that disrupt the absorption, chronic disease, surgical history to be studied from an ethological point of view. The relationship between vitamin B12 levels and Htc, MCV, homosysteine, folate levels and thyroid function tests has been statistically evaluated. Results: There was no statistically significant difference in B12 levels between age groups. 56 of 115 patients (48.69) did not find any of the etiological factors. Vitamin B12 deficiency caused by the use of the proton pump inhibitors and the lack of intake was detected. There is no meaningful connection between the thyroid hormones and the vitamin B12 levels, while a weakly meaningful negative correlation between the values of homosexuality has been found. The result: Vitamin B12 deficiency was identified as the cause of drug use and intake deficiency. In 48.69% of patients, no etiological cause was found. Vitamin B12 deficiency is still facing us as a major health problem worldwide. Therefore, further research is needed. Key Speaker ̈kler: Vitamin B12 deficiency; Hematocrit; MCV; Folate; Homosysteine, thyroid function tests. ABSTRACT Objectives: Vitamin B12 plays a role as coenzyme in the chemical reactions involved in DNA synthesis and deficiency is still a common health problem in our society. In our study, we investigated the etiology of vitamin B12 deficiency and the relationship of this deficiency with MCV, homocysteine, folic acid levels and thyroid function tests Material and Methods: 115 patients with vitamin B12 deficiency, who admitted to the Haseki Education and Research Hospital between July 2009 and September 2009, were included in the study. All patients were recorded and analyzed for etiologic factors age, deficiency in dietary, using drug use, chronic illness, operations. We investigated the etiology of vitamin B12 deficiency and the relationship of this deficiency with MCV, homocysteine, folic acid levels and thyroid function tests Results: There was no statistically significant difference in B12 levels among the age groups. No one of the etiological factors was found in 56 of 115 patients (48.69%). The most common cause of vitamin B12 deficiency was proton pump inhibitor using in 28 patients (24.4%) and 19 patients had low food intake. A significant correlation was also not observed between thyroid hormones and vitamin B12 levels. There was a significant negative correlation between B12 levels and homocysteine levels. Conclusion: we found the most frequent use of PPI and the low intake of dietary supplements for possible causes of vitamin B12 deficiency in our study. As vitamin B12 deficiency is still an important health problem all over the world, further research is needed. Keywords: Vitamin B12 deficiency; Hematocrit; MCV; Folate; Homocysteine; Thyroid function tests.

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