The purpose of this research is to examine the role of self efficacy and burnout on the alienation of psychological counselors. The research was carried out with 203 psychological counselors working in the center and counties of Trabzon, Rize and Artvin in the academic year of 2016-2017o whom 134 (66.00%) were female and 69 (34.00%) were male. The results of the study indicated that there was a moderate and negative relationship between self efficacy and alienation, moderate and positive relationship between burnout and alienation, and moderate and negative relationship between self efficacy and burnout. The study revealed that self efficacy and burnout were positively correlated with alienation at a high level, and that self-efficacy and burnout explained 50% of alienation. Although self efficacy and burnout explained alienation in a meaningful way, burnout was found to be a stronger predictor.