Abstract:

Introduction: The important side effects of treatment given due to cancer is the primary cause of morbidity and mortality. The American Association of Infectious Diseases is considered a high-risk characteristic, such as the current neutropen for longer than seven days and deep neutropen (the absolute number of neutrophils <100/mm3). The urgent approach during the Febril neutropenic attack is the application of antibiotic therapy, which has a broad spectrum of antipsodomonal effect, to the patient in time when it is intravenous. This study was aimed at studying the attacks of febril neutropene in children with cancer during the period of 27 months of a hospital serving the third stage. Instruments and Methods: In cases treated due to hematological or solid organ cancer between January 2012 and March 2014, febril neutropenic attacks developed retrospectively from the files. Febril neutropene is defined as the presence of fire from the seat that accompanies the absolute number of neutrophils below 500/mm3 or between 500-1000/mm3 and is expected to fall below 500/mm3 within 48 hours once measured at 38,5 ̊C or seen above 38 ̊C for an hour or measured above 38 ̊C twice over four hours.  The findings: 131 febril neutropenic attacks in 48 patients with an average age of 7.1 ± 5.3 years were studied retrospectively. 75% of the patients were diagnosed with leukemia. In the first 24 hours, 69% of fire controls were provided during the attacks. In blood or catheter culture, a gram-negative bacterium was detected in 36% of reproductive attacks and in 64% of reproductive attacks. In 32% of piperasillin-tasobaktam attacks, which began ampirically in patients, was sufficient for treatment. In 19% of attacks for support, the granulocyte colony stimulating factor was applied. Discussions:A wide spectrum of antibiotic therapy should be initiated in cases where the bone marrow develops after chemotherapy or where the bone marrow does not work for other reasons to reduce the patient's morbidity and mortality.

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