Abstract:

In recent years, the incidence of chronic diseases such as obesity, dyslipidemia, cardiovascular diseases, type 2 diabetes is increasing. The role of dietary pattern in the emergence and progression of chronic diseases is well known. One of the most important parts of a sufficient and balanced diet is the fat taken with food. Especially in recent years, the role of different fatty acids as well as the total amount of fat taken with diet has been focused on. Palmitoleic acid, one of these fatty acids, is a sixteen-carbon, monounsaturated fatty acid. Palmitoleic acid is metabolized mainly in adipose tissue and liver. The amount found in the body varies specifically for the tissue and the region. However, basal concentrations of palmitoleic acid vary depending on metabolic processes. Therefore, palmitoleic acid is thought to be a "lipokine" released from adipose tissue and palmitoleic acid metabolism may be effective in preventing chronic diseases. More comprehensive cohort, longitudinal and randomized controlled studies are needed to explain the effects of palmitoleic acid. In this review, the possible role of palmitoleic acid supplementation in the formation of chronic diseases such as obesity, type 2 diabetes and cardiovascular diseases was examined in the light of recent studies.

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