Abstract:

Aim: Desmoid tumors (DT) originate in musculoaponeurotic tissues. However, there is scarce data regarding DT-related clinical and oncological outcomes. This study presents the oncological outcomes of patients who underwent surgery for abdominal DT in our clinic over a 10-year period and compares the outcomes between sporadic and familial adenomatous polyposis (FAP)-associated DTs. Method: The records of patients who underwent surgery for DT between January 2011 and 2021 were retrospectively analyzed. Results: The study included 18 patients, of which 15 were female, and with a median age of 43 (range: 21-59) years. Of the 18 cases, four developed DT following surgery for FAP coli syndrome. The mean age was lower in patients with FAP-associated DTs than in those with non-FAP-associated tumors (28 vs. 46.5 years, p=0.574). After a follow-up period of 68.1 months (95% confidence interval: 12,799-123,519), four patients developed recurrence, and the recurrence rate was higher (50% vs. 14.28%, p=0.130). Additionally, the time to recurrence was shorter in patients with FAP-associated DTs than in those without FAP (31.3 vs. 120.9 months, p=0.028). The tumor board decided that adjuvant tyrosine kinase inhibitor therapy would be administered to four patients and adjuvant 50.4 Gy radiotherapy to three patients. Conclusion: DT are more common in women. As recurrence is more common and the time from index surgery to recurrence is shorter in patients with FAP-associated DTs, more intensive follow-up protocols would be necessary in this group.

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