Özet:

Objective: There are numerous studies showing that in the pathogenesis of Alopecia Areata, immunity through the variable T cell plays a role. Due to the important role of cytokins and chemicins in the immune process of Alopecia Areata, this study was conducted in order to investigate the possible link between the tendency to Alopecia Areata and TNF-α-308G/A polymorphism in the Turkish population. READ AND METHOD: The presented case control study included 107 Alopesi Areata patients and 113 healthy control individuals. Genotyping of TNF-α-308G/A polymorphism was performed by methods of Polymerase Chain Reaction (PZR) and Restriction Enzyme Analysis (REA). Notes: There was no meaningful connection between the distribution of TNF-α-308 G/A genotypes and allel frequencies in patients and control groups (p=0.673 and p=0.177, respectively). Similarly, the difference between TNF-α-308 G/A polymorphism and the clinical findings of Alopecia Areata was not identified. This study shows that TNF-α-308 G/A polymorphism does not play an important role in the development of Alopesi Areata in the Turkish population.

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