Özet:

Purpose: In patients at risk of ovarian hyperstimulation syndrome (OHSS), anjiotensin-transforming enzyme (ACE) gene insection/delition (I/D) polymorphism is to determine whether it has an effect on the development of ovarian hyperstimulation syndrome. Tools and methods: 47 infertile patients who were included in the ovulation induction program for the treatment of auxiliary reproductive techniques, with a level of estradiol above 3000 pg/ml on the day when human coronary gonadotropin was done, with a high risk of OHSS development. The patient’s age, infertility time, total dose of gonadotropin used, induction time, the number of follicles obtained, endometrium thickness and infertility cause were recorded. Control (n:25) and OHSS (n:22) groups of patients with ACE gene's insection/distribution polymorphism were tested by PCR method. Results: Age, infertility time, gonadotropin dose, induction time, endometrium thickness measurements showed no significant difference between the two groups. The number of follicles was found at 17.1 ± 4.2 OHSS in the control group at 25.4 ± 6.8. The difference between the two groups is meaningful (p<0,001). In the OHSS group, the ACE gene D allel frequency was 56.8% in the control group 54,0% and the D allel frequency was 55.3% in the total of 47 patients. When compared to the OHSS and the control group for the ACE genotype, there was no significant difference between the two groups in terms of II-ID-DD genotypes (p>0,05). The probability of having genotype DD in the OHSS group is 1.47 times higher than the control group (OR: 1.47% 95 confidence limit, 0.44-4.86) but is not statistically meaningful. Result: The study studied in patients with high risk for OHSS ACE gene insection/deposition polymorphism. The ratio of DD genotype is not different in OHSS and control group. ACE gen is not considered an active factor in the development of insection/dissection polymorphism, OHSS.

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