Özet:

Purpose: Increasing day by day, cancer is a serious global health problem of our age and lung cancer is the most common cancer in the total number of cancers worldwide. Angiogenesis plays an important role in the development and metastasis of tumors. It has been shown that microvessel density (MY) calculated with different endothelial markers is associated with poor prognosis and advanced stage in some tumors and from there it is suggested that metastasis can be predicted. In our study, we aimed to detect MY immunohistochemically with endoglin, CD31 and VEGFR2 in non-small cell lung cancers (KHDAK), correlate it with serum endoglin level and compare our results with the progression of lung tumors. Materials and methods: In our study, the expression of endoglin (CD105), CD31, VEGFR2 from angiogenic factors was examined immunohistochemically in a total of 72 lung tissues, 36 of which were squamous cell carcinomas (SHK) and 36 were adenocarcinomas. Endoglin level was determined by Elisa method from blood taken from 26 volunteers and 26 healthy volunteers diagnosed with primary lung cancer. Results: We observed that endoglin has a greater affinity for activated endothelial cells. Both tumor types showed nonspecific CD31 staining, and MY was difficult to determine. On VEGFR2 stained sections, diffuse positivity was detected in the vessel walls inside and outside the tumor. It was found that the blood endoglin level was not statistically significant between the KHDAK and the control group. Immunohistochemically, there was no difference statistically significant between endoglin, CD31 and VEGFR2 expression and survival. Conclusions: As a result of our study, we think that immunohistochemically specific stained endoglin in KHDAK may be a better marker in the evaluation of angiogenesis in patients with both SHK and adenocarcinoma types.

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