Özet:

Although DNA is stable, it is a molecule likely to be damaged by endogenous and exogenous sources. If the resulting DNA damage is not repaired; adverse events may occur in the cell such as apoptosis and aging, and genomic mutations in DNA. Therefore, organisms have developed a number of DNA repair mechanisms that are appropriate for them. These repair mechanisms are very important for the integrity and continuity of life. DNA damage plays a role in the pathogenesis of neurodegenerative diseases. As neurons are postmitotic cells, mutations in base loss mutations and DNA chain breaks are more common, whereas the brain uses 20% of the available oxygen, DNA damage occurs due to oxidative stress. Also the presence of neurodegenerative disease changes the functioning of DNA repair mechanisms. This review will discuss DNA repair mechanisms and the role of DNA repair mechanisms in Huntington's disease, Alzheimer's disease, Parkinson's disease, Amytrophic Lateral Sclerosis, Friedreich's Ataxia, Ataxia Telangiectasia and Hereditary Spastic Paraplegia.

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