Özet:

Introduction: The data on the actual frequency of the reactions of over-sensitivity arising with drugs is limited. There have been various publications in the world and from various regions of our country reporting the frequency of drug allergies and the distribution of drug allergies. This study was aimed at contributing to the existing data by investigating the frequency and distribution of drug allergies in the Sakarya region. Tools and Methods: Documents of patients applying for drug allergy from 2016 to 2018 to the Adult Allergy and Immunology Clinic of the University of Sakarya Education and Research Hospital were reviewed backward. Research is an identifiable research. 108 patients were involved in the study. The patient’s age, gender, suspicious drug(s) that caused the reaction, skin test and oral provokation test results, placebo and symptom rates, and medication data they could safely use as an alternative were studied. Results: 105 of 213 patients with drug allergy were allergic to nonsteroidal anti-inflammatory drugs (NSAIDs) through cox-1. The remaining data of 108 patients with early type 1 drug allergy was examined. The woman/man ratio was 96 (%88.9)/ 12 (%11.1), the average age was 44.1 ± 12.1 Standard Sappma. The history-based drug allergy distribution was found in penicillin 55%, sefalosporin 46.7%, analgesics 38%. 38 patients were tested with 53 suspicious medications, 80 patients with 105 alternative medications. In the tests with suspicious medication, 17 (44.7%) patients were positively identified. In the test for alternative purposes, a positive rate was 11.4%. The result: The assessment by diagnostic tests of patients who apply for the cause of drug allergy finds that most of them are not actually drug allergic. Therefore, it is possible to conclude that the immediate ban of history-based medications in drug allergies is not correct and that in the alternative drug sequence it is necessary to conduct tests before.

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