Abstract:

This study was done to determine oxidative stress and changes in some biochemical parameters in leptospirosis. The material of the study was created by a total of 20 funds consisting of 10 healthy funds in the same age with 10 leptospirosis diagnosed in 3-5 months. In all animals, malondialdehyd (MDA), plasma catalase (CAT) and glutathiyonperoxidase (GSH-Px), total protein, albumin, alkaline phosphate (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma glutamiltransferase (GGT), blood urine nitrogen (BUN), glucose and total bilirubin levels have been determined. The study found that the MDA levels were statistically higher (P<0.01) compared to the control group in the leptospirosis group, while the GSH-Px and CAT levels were lower (P<0. It was found to be 05. ALP, AST, LDH, GGT, BUN, total bilirubin and total protein levels were found to be higher than controlled in patients with leptospirosis, while albumin and glucose levels were low in the patient group. As a result, leptospirosis cells have been found that oxidative stress develops during the disease and biochemical data have been obtained indicating that the liver and kidney are affected in this disease.

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