Özet:

Background: The pathogenesis of diabetic nephropathy (DN) is very complex and is still not well understood. SUA has been associated with metabolic risk in a wide range of diseases. In this study, we aimed to investigate the effect of SUA and SUA/Scr ratio on renal function using glomerular filtration rate (GFR) and microalbuminuria. Methods: A total of 399 patients with diabetes alone, excluding other conditions that affect uric acid levels, were included in the study. Patients were divided into normoalbuminuria (n:247) and microalbuminuria (n:152) groups. SUA, SUA/Scr ratios were compared. Results: Female gender was 53.4% in the normoalbuminuria group and 57.9% in the microalbuminuria group. There was no significant difference in gender between the groups. In the microalbuminuria group, SUA (p=0.032), glucose (p<0.001), GGT (p=0.003), HBA1C (p<0.001), and triglycerides (p<0.001) were significantly higher, while eGFR (p<0.005), HDL (p<0.001), and vitamin D (p=0.017) were significantly lower. There was a significant negative correlation between eGFR and SUA (p<0.001) and albuminuria (p=0.004) and a significant positive correlation between eGFR and SUA/Scr ratio (p<0.001). Conclusion: Serum uric acid (SUA) levels have been found to be associated with renal function in diabetes. Our study confirms this association. The metabolic and microvascular effects of SUA are widely recognized. Nevertheless, further evidence is required to clarify the relationship between SUA/Scr ratio, which accounts for renal function, and DN.

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