Abstract:

Warthin-like papillary thyroid carcinoma is a rare variant of papillary thyroid carcinoma with favorable prognosis. The tumor is named “Warthin-like papillary thyroid carcinoma” because of bearing a striking morphological resemblance to Warthin\'s tumor occurring in the salivary glands. Thy­roid ultrasonography of 65 years old female patient with a history of bilateral subtotal thyroidectomy 30 years ago in another center with unknown histopathological diagnosis revealed a 20 mm isoechoic solid nodule in the left lobe and this nodule was hypoactive in thyroid scintigraphy. Grossly, a grey-tan colored, solid nodule with 1 cm di­ameter was seen in the left lobe. Histologically, the tu­mor was composed of papillary structures surrounded by marked lymphocytic stroma and oncocytic cells with papillary carcinoma\'s nuclear features were lining the papillae. Hashimoto\'s thyroiditis was present throughout the thyroid. Immunohistochemically, tumor cells exhib­ited cytokeratin 19, Thyroid transcription factor-1 (TTF-1), Galectin-3, HBME-1(Mesothelioma antibody) and thyro­globulin positivity, proliferative index with Ki-67 was low. Warthin-like papillary thyroid carcinoma is a rare variant of papillary thyroid carcinoma and other oncocytic cell le­sions especially Hurthle cell carcinoma should be kept in mind in the differential diagnosis of this neoplasm.

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