Abstract:

Invasive ductal carcinoma which is breast cancers is the most common breast cancer in women. In these tumors, early diagnosis and appropriate medical treatment is to markly influence the life span. For this reason, breast cancers is occured intensive at therapy with chemotherapeutic agents and hormonal treatment for the purpose of prevention systemic spread and prognosis determination of works in the last years. Just reliable determinatives are necessary, because of not to be adequate to orientate treatment and prognosis only classıc parameters. For this reason, it was evaluated the correlation with each other and other prognostic factors of bcl-2 and cathepsin D in invasive ductal carcinomas of the breast in the present study. Materials and methods: In the present study. It was included 50 cases diagnosed with invasive ductal carcinoma and examined mastectomy and axillary dissection material. Slides stained with estrogen, progesterone and c-erbB-2 were reviewed again and done scoring separately for each slide.Also in the present study it was stained bcl-2 and cathepsin D expression in 50 invasive ductal carcinomas by immunehistochemistry, and evaluated the correlation with other prognostic factors and each other. Results: A strong positive relationship was not detected between bcl-2 expression with other prognostic factors and cathepsin D protein, while a strong positive relationship was detected between bcl-2 expression with low nuclear grade and progesterone receptor' status. A strong correlation was not observed between cathepsin D expression with estrogen receptor' status and progesterone receptor' status and c-erbB-2 oncogen amplification and other prognostic factors, while a strong correlation was also observed between cathepsin D expression with high nuclear grade and blood vessel invasion and lymph-vessel invasion and perineural invasion. Conclusion: Bcl-2 is thought to be important in determining of invasive ductal carcinoma cases with low grade, while cathepsin D is thought to be important in determining of invasive ductal carcinoma cases with high grade and invasion ability.

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