Abstract:

Diabetes mellitus (DM) is a global health problem with increased risk of vascular disease. Platelets may contribute to the development of vascular complications in subjects with diabetes. Larger platelets are more reactive than smaller ones therefore, mean platelet volume (MPV) can be used as a marker for platelet activity. Aim and Objectives: To determine the role of MPV in severity and complications of DM2 as compared to non diabetic patients and to determine the effect of glycemic control and duration of diabetes on platelet parameters. This is a cross-sectional prospective study to evaluate MPV in patients with diabetes mellitus 2 versus non-diabetic patients and to investigate the potential association between MPV and chronic diabetic complications. Our study revealed that MPV is increased in Diabetes mellitus (DM) and that platelets become more reactive and aggregable. The increased platelet size may be a risk factor for atherosclerosis associated with DM and its vascular complications. MPV was found to be higher in subjects with Type-2 diabetes and significantly increased in diabetics with poor glycemic control and In patient with complications. having a longer duration of diabetes. MPV can be used as a prognostic marker of vascular complications in patients with DM.

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