Abstract:

Cadmium (Cd), which enters the structure of batteries, plastic substances and pigments in the form of metal alloys, has many toxic effects in the body. Considering the importance of environmental health of Cd, which can also be the cause of cancer due to its affinities that lead to enzyme inhibition and nuclear acids, the pathological effects were studied by creating experimental studies. In the study, 24 rabbits were used and 18 rabbits who formed the trial group were given 2 mg/kg cadmium subcutaneously daily for 6 weeks. During the study, four rabbits were found dead. The necropsy of the dead rabbits was taken with tissue samples. Periodically, at the end of each week, necropsy was performed by cutting from the trial group of 3 and 1 rabbits from the control group, including the dead. Makroscopically, it attracted attention to growth in the liver, necrotic concentrations and acid. In the microscopic examination, findings such as degeneration in hepatosites in the liver, necrosis, perivascular mononuclear cell infiltration, proliferation of the gall canal were recorded as findings developing in different times during the test period. In the kidneys, degeneration, necrosis and desquamation in the tubulus epithels, calcium accumulations in the tubulus in the past days, neuron degeneration and necrosis in the brain have developed. In the dead rabbits, the hyperemia and hemorrhage in the liver and kidneys, in addition to these injuries, were more severe than in the survivors.

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