Abstract:

Primary Bone Lymphoma (PBL) is a subtype of lymphoma that exclusively affects the skeletal tissue.Primary Bone Diffuse Large B Cell Lymphoma (DLBCL) is the most common pathological type, comprising about 80% of PBL. In this case report, we discuss a patient, a 50-year-old lady who presented with solitary bone lesion, confirmed by biopsy and IHC as DLBCL. She was diagnosed as stage IAE as per WHO staging system. Chemotherapy with R-CHOP for a total of 6 cycles were given followed by IFRT. The patient is under follow up with complete response at present. Being rare case, no randomised study can be taken up for standard treatment protocol. Case to case individualised treatment is done based on stage, histopathological subtype and predictive biomarkers to response. PBL is more common in paediatric population more than the adults.The prevalence of PBL is estimated to be 3-7% amongst all lymphomas in adults.1 WHO classification of soft tissues and bone tumors defined PBL as either single osseous lesions without regional Lymph node involvement , or tumor involvement of multiple osseous sites without associated visceral or Lymph Node disease.2

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