Abstract:

Purpose: Local advance and/or lymphatic nodes are diagnosed with rectum cancer and long-term neoadjuvant chemoradiotherapy is intended to determine the rates of tumor and nodal decline and pathological response in cases. Method: In the Department of Radiation Oncology of the Mersin City Education and Research Hospital, the data of 23 rectum cancers with local advanced or lymph nod metastasis, which was applied neoadjuvan chemoradiotherapy in 2017, were evaluated as retrospective. Chemotherapy and radiotherapy are applied simultaneously. Twenty-one incidents were performed curative surgery four to eight weeks after the end of neoadjuvan chemoradiotherapy. The assessment of the response to Neoadjuvan chemoradiotherapy was made by comparing the pre-operative stage with the pathological universe. The absence of any cancer cells in the resection material was considered a pathological complete response. The decline in the tumor and nodal stage was considered as a partial response. Results: The average age of the cases was 57.3±9.8. In pre-treatment radiological examinations, T4 tumors were detected in 9 of the cases (39.1 percent) in T3, 14 percent (60.9 percent). In 14 cases (60.9%) lymph nod metastasis was not observed, while in 9 cases (39.1%) lymph nod metastasis was detected. The location of the tumor was 8 (%34.8) the lower rectum, 7 (%30.4) the middle rectum, 8 (%34.8) the upper rectum. Sphinkter could be applied to 71.4% of the surgical cases. In 7 of the post-Neoadjuvan chemoradiotherapy cases (30.4%) the pathological complete response was observed, and in 13 (56.5%) the partial response was observed. No significant difference has been observed in statistical analysis between the reaction to the Neoadjuvan therapy and the tumor placement and the applicability of the sfinkter protective surgery Result: Neoadjuvan chemoradiotherapy may result in a tumor size and/or stage decline in most of the cases. The scale decline does not increase the applicability of the sfinkter protective surgery.

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