Abstract:

Objective: Deep venous thrombosis (DVT) is a serious clinic problem and leads to severe complications such as pulmonary embolism, post-thrombotic syndrome and pulmonary hypertension. High serum lipoprotein and lipid levels have an effect on atherogenesis and also trigger the development of DVT. Our study aimed to investigate the total cholesterol and triglyceride levels in patients with DVT. Material and Methods:Between October 2012 and July 2014, 63 of the patients diagnosed to our hospital with deep venous thrombosis were included in our study. The diagnosis of DVT was based upon Wells scoring system and serum D-dimer level and confirmed by deep venous Doppler ultrasonography. Fasting total cholesterol, low-density lipoproteins (LDL), high density lipoproteins (HDL) and triglyceride levels were measured before starting the treatment of DVT. Also, biochemical parameters including creatinine phosphokinase (CPK) were regularly tested for avoiding severe complications in patients using lipid lowering drugs. Results: There were 32 male and 31 female patients ranging in age from 17 to 83 years, with a mean age of 53.57 years. Twenty five (39.7%) patients had elevated total cholesterol levels. Twenty five (39.7%) patients had elevated triglyceride levels of whom 12 (48%) had also increased total cholesterol levels. All patients gave a positive response to anticoagulant therapy and improved clinically. Cholesterol and triglyceride levels were gradually decreased to normal serum levels with proper treatment. There were no recurrences during the follow-up period.Conclusion:Our data suggest that in contrast to elevated HDL levels, elevated cholesterol or triglyceride levels may play a contributing role in the occurrence of DVT. Also, in addition to anticoagulant therapy, the adjustment of cholesterol and triglyceride levels to the normal limits may be useful to avoid recurrence of DVT. However, further investigations are required to clarify the relation among the high total cholesterol and triglyceride levels and DVT

Keywords: