Abstract:

Purpose: The aim of this study is to evaluate the effect of Nerium oleander distillate on the serum biochemical parameters of hypercholesterolemic rats. Tool and Method: Three equal groups consisting of 30 male Sprague-Dawley wheels were formed. There was no application for the control group. The second group was given a high-cholesterol diet, while the third group was given a high-cholesterol diet, in addition to Liofilize Nerium oleander distillate, once a day through oral gathering. Three months later, the blood was taken from the rats under sedation and the euthanasia was made. Serum hunger blood sugar, triglyceride, high-intensity lipoprotein, total cholesterol, low-intensity lipoprotein, alanin aminotransferase, aspartate aminotransferase, albumin, total protein, alkaline phosphatase, lactate dehydrogenase, creatine and urine levels were determined in the autoanalyzer. Results: In the group feeding with a high cholesterol diet, compared to the control group, the levels of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, glucose, low-intensity lipoprotein and triglyceride increased (p < 0.05). However, the Nerium oleander application increased as aspartate aminotransferase, cholesterol, low-intensity lipoprotein and triglyceride levels (p < 0.05) were found. Recommendation: In summary, it can be stated that Nerium oleander distillate has antihypercholesterolemic and liver protection properties.

Keywords: