Abstract:

Introduction: Intestinal amyloidosis frequently encountered as a part of systemic amyloidosis, but rarely can be confined in the gastrointestinal tract. Case report: A 54-year-old male presented with the complaint of gas and stool discharge. Urgently segmental bowel resection was performed for ileus. Macroscopically nodular lesions, the largest at 7x3x0.7 cm in size were observed in the intestinal lumen. Microscopically the accumulation of dense eosinophilic material that formed a mass in the submucosal area was noted. This material was positive with Crystal Violet, Congo Red and Amyloid A. Kappa and Lambda were negative. No monoclonal gammopathy, increase in serum amyloid A levels, chronic inflammatory disease, infectious disease or malignancy was determined. The case was evaluated as "intestinal AA amyloidosis". Discussion: While AA amyloidosis was existent in our case, it comprised a mass lesion and caused intestinal obstruction. It is also exraordinary for AA amyloidosis to be confined in gastrointestinal tract.

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