Abstract:

Objectives: The aim of this research is to study the link between lipid lowering mechanism and other beneficial biological effects of statin in patients of coronary bypass surgery by revealing the relation of preoperative statin on pre- , peri- and postoperative cardiolipin IgG and IgM antibody levels. The case in open cardiac surgery was not keeping the heart beating only but preventing or minimizing the myocardial injury. For this reason, a new method for preservation of blood elements and myocardium must be uncovered. Material and Methods: Thirty patients with coronary ischemic disease whose scheduled to undergo elective coronary artery bypass graft surgery and fitting the criteria for our research were divided in to two groups, those on standard lipid lowering therapy using atorvastatin ( 40 mg/day ) for at least 7 days prior to surgery (group A) and second group those without regular lipid lowering therapy preoperatively (B). All the parameters were documented and recorded, including demographic, hemodynamic, laboratory and surgical technique with outcome. Results: The recorded parameters and values were analyzed using the following tests in computer program: Kolmogorov- Smirnov test, student t test, paired t test and Chi- square test. All results were scheduled in 6 tables for simple and better evaluation. Conclusion: The findings support the beneficial effects of statin in the perioperative and early postoperative (first 24 hours) in open cardiac surgery.

Keywords: