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  Citation Number 1
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FİBROMİYALJİLİ HASTALARDA KİŞİLİK ÖZELLİKLERİNE GÖRE PREGABALİN VE DULOKSETİN TEDAVİLERİNİN ETKİNLİĞİNİN KARŞILAŞTIRILMASI
2016
Journal:  
Düzce Tıp Fakültesi Dergisi
Author:  
Abstract:

Çalışmamızda fibromiyalji sendromlu (FMS) hastaları kişilik özelliklerine göre ayırıp,kişiliklerde duloksetin, pregabalin tedavisinin etkinliklerini araştırmak, etkinlikleri birbirleriylekarşılaştırmak amaçlandı. FMS’li 102 kadın hasta Eysenck Kişilik Anketi kullanılarak kişiliközelliklerine göre gruplandırıldı. Her kişilik grubu kendi arasında rastgele iki gruba ayrıldı. 12hafta süreyle gruplardan birine 60 mg/gün duloksetin, diğerine 300 mg/gün pregabalin tedavisiuygulandı. Hastaların tedavi öncesi ve sonrası ağrı şiddetleri Visual Analog Skala, uyku kaliteleriVAS-uyku skoru, depresyonları Beck Depresyon Ölçeği (BDÖ), yaşam kalitesi SF-36,fonksiyonel durumları Fibromiyalji Etki Anketi (FIQ) ile değerlendirildi. Tedaviye alınan hastaların 61’i (%59,8) nörotik, 41’i (% 40,2) dışa dönük kişilik özelliğindeydi.Nörotik grubun 30’u duloksetin, 31’i pregabalin; dışa dönüklerin 20’si duloksetin, 21’ipregabalin tedavisine alındı. Her iki ilaç SF-36’nın enerji, fiziksel rol güçlüğü, genel sağlık,ağrı, mental sağlık boyutlarında kişilik özelliklerinden bağımsız düzelme sağladı. Fizikselfonksiyonda duloksetin alan nörotik ve pregabalin alan dışa dönük grupta düzelme oldu.Emosyonel rol güçlüğünde nörotiklerde ilaçlardan bağımsız düzelme saptandı. Sosyalfonksiyonlarda hiçbir grupta iyileşme olmadı. FIQ skorunda düzelme ilaçlardan bağımsız dışadönük grupta daha fazla görüldü. BDÖ’ de düzelme duloksetin alan nörotikler ve pregabalinalan dışa dönüklerde oldu. Hassas noktalar ve VAS’da bütün gruplarda düzelme oldu. Ancakduloksetin alan nörotiklerde ve pregabalin alan dışa dönüklerde düzelme daha fazla oldu. VASuyku skorları tüm gruplarda düzelme gösterdi. FMS tedavisinde kişilik özellikleri önemlidir.Dışa dönükler tedaviye daha iyi cevap vermektedirler. Tedaviye öncelikle dışa dönüklerdepregabalin, nörotiklerde duloksetin başlanmalıdır

Keywords:

The effectiveness of Pregabalin and Duloxetin treatments according to personal characteristics in fibromyalgia patients
2016
Author:  
Abstract:

Our study aimed at distinguishing patients with fibromyalgia syndrome (FMS) according to their personality characteristics, researching the effectiveness of duloxetine, pregabalin treatment in personality, comparing the effectiveness with each other. 102 women with FMS were grouped according to their personality characteristics using the Eysenck Personality Survey. Each individual group was divided into two groups. During 12 weeks, one group was given 60 mg/day duloxetine and the other 300 mg/day pregabalin. Patients' pain severity before and after treatment was evaluated by Visual Analog Scale, Sleep QualityVAS-Sleep Score, Depression Beck Depression Score (BDÖ), Life Quality SF-36, Functional Conditions Fibromyalgia Effect Survey (FIQ). 61 (59.8%) of the patients treated were neurotic, 41 (40.2%) were external personality.30 of the neurotic group were duloxetine, 31 pregabalin; 20 of the external were duloxetine, 21 isipregabalin. Both medications provided an independent improvement of the personality characteristics of the energy, physical role difficulties, general health, pain, mental health dimensions of SF-36. In physical function, the area of duloxetine and the area of pregabalin had an improvement in the external group.In the emotional role deficiency, the neurotics had an independent improvement of drugs. There was no healing in any group of social functions. Correction in the FIQ score was more observed in the group of exoplasty independent of medications. In BDÖ, the correction of the duloxetine area was the neurotics and pregabalinalan in the outside directions. There were sensitive points and improvements in VAS in all groups. However, there was more improvement in the neurotics in the area of duloxetine and the external areas in the area of pregabalin. The scores of VASuyku showed improvement in all groups. Personality characteristics are important in the treatment of FMS.The external responds better to the treatment. Treatment should first start in the external directionpregabalin, duloxetine in the neurotics

Keywords:

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Düzce Tıp Fakültesi Dergisi

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

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Düzce Tıp Fakültesi Dergisi