Abstract:

Background: Cervical cancer is the most common gynecologic malignancy and the leading cause of cancer-related mortality in women worldwide. Systemic inflammatory reactions in cancer patients impact nutrition, function, and prognosis. Poor nutritional health is linked to a worse prognosis in several malignancies. A new score called the hemoglobin-albumin-lymphocyte-platelet (HALP) index was developed using dietary and inflammatory deficiencies. Method: This retrospective study and CC patients diagnosed from January 2012 to December 2020 who were operated for cervical cancer. Pre-treatment hemoglobin (Hb), albumin (Alb), lymphocyte count (Lc), and platelet (Plt) measurements were made for laboratory research. Results: This retrospective study revealed 74 non-metastatic cervical cancer (median age was 55, ranging from 30 to 86 years). According to the FIGO stage, the percentage of stages 1 and 2 were 78% (58 patients), and 22% (16 patients). Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), and HALP index were analyzed with LVSI, parametrial invasion, tumor size, histologic type, and duration of hospital stay; we could not find any significant correlation between the analysis. Conclusion: NLR, PLR, and HALP index have no prognostic value in early operable cervical cancer patients regarding the pathologic features. Prospective multicenter and more patient studies will clarify how the hematologic parameters affect oncologic outcomes.