Özet:

Paget’s disease of bone (osteitis deformans) is a focal and chronic skeletal disorder characterized by an accelerated rate of bone turnover with excessive resorption and formation of bone. Most of the patients are asymptomatic. Main clinical manifestations of Paget’s disease in symptomatic patients are pain, deformities and fractures in affected areas. Paget’s disease should be strongly suspected in a healthy older patient who has a high serum alkaline phosphatase concentration, a normal serum calcium concentration, and no evidence of hepatobiliary disease. A radionuclide bone scan is more sensitive than plain radiographies in identifying pagetic bone lesions. Serum calcium and phosphorus concentrations are normal in most patients with Paget’s disease. However, hypercalcemia, hypocalsemia, primary or secondary hyperparathyroidism can occur. Primary indications for treatment are to relieve symptoms and to treat or prevent complications associated with the disease. Calcitonin and bisphosphonates are specific antipagetic drugs.

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