Özet:

The thrombosis that occurs with a disturbance of the anticoagulant and procoagulant balance, which forms symptoms according to the location, due to hereditary or inherent causes, is the cause of significant morbidity and mortality. In this study, we aimed at identifying the ethological risk factors in patients with atypically settled and young (40 and 6 years old) trombosis diagnosed. MATERIAL-METHOD: In our retrospective study, patients under the age of 40 were selected with typical localized thrombosis and patients with atypical localized thrombosis at any age. The highest etiological risk factors in patients with atypical thrombosis were scaned in terms of hereditary and genetic causes. The localization of the trombosis has been examined by the highest risk factors. BULGULAR: 32 of the women in our work (34.78±14 years of age). 34) 18 were included in 50 patients (age: 35.22±13.56) including men (age: 36±12.41) . 12 of the patients (24%) were over 40 years old and 38 (76) were under 40 years old. In 7 patients (%14) due to oral contraceptive (OKS) use, in 6 (%12) after surgery, in 1 (%2) during pregnancy, in 1 (%2) due to immobilization, in 2 (%4) due to hypertension, secondary thrombosis was detected. MTHFR C677T, homozigot was detected in 8 (%16) patients, heterozigot in 4 (%8) patients. MTHFR A1298C was identified in 8 (%16) patients with homozigot, 12 (%24) patients with heterozigot and MTHFR A1298C/C677T with heterozigot association in 6 (%12) patients. In 7 of the patients (%14) essential trombositosis and in 4 of these patients (%8) JAK2 mutation was detected. Malignity history was diagnosed in 1 (%2), thalassemia major 1 (%2) and SLE 1 (%2). Faq-V leiden mutation 3 (%6), protein-S deficiency 1 (%2), anti-thrombin III deficiency 2 (%4) were detected in patients. Protrombin gen mutation was detected as heterozigot in 2 (4%) patients. Lupus anticoagulant 2 (%4) in patients, fibrinogenic levels 1 (%2) in patients were high. PAI-1 (4G/5G) gen polymorphism was detected in 5 (10%) patients. In 31 patients diagnosed (62%), hereditary and inherited risk factors were identified together. In 6 patients (12%) no hereditary or inherent risk factor was identified. Typical trombosis found in atypical localized thrombosis and adult patients under the age of 40 can be identified in combination with hereditary and edental etiological risk factors. It was found that myeloproliferative diseases should be assessed as an ethological factor in the abdominal thrombosis and that the risk of thrombosis increased in the presence of hereditary risk factors underlying the use of OCS in women. For reasons such as pregnancy, lactation, use of OCS, more thrombosis was found in the female sex.

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