Özet:

Objective: The aim of this study was to investigate the effects of 2.45 GHz electromagnetic radiation (EMR), which may cause hematological and biochemical changes in blood. We preferred Vitamin C (Vit C) for its protective properties effects against the effects of EMR exposure. Material and Method: For this study, 18 female Sprague Dawley rats were randomly divided into three groups with six animals in each: Sham, EMR and EMR+Vit C groups. Sham group: 0.1ml/day saline for 30 days, by oral gavage; EMR group: EMR, 1h/day for 30 days; EMR+Vit C group: EMR, 1h/day for 30 days+Vit C 250 mg/kg/daily, by oral gavage. White Blood Cell (WBC), Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil, Red Blood Cell (RBC), Hemoglobin (Hb), Hematocrit (Htc), Mean Erythrocyte Volume (MCV), Red Cell Distribution Width-SD (RDW-SD), Red Cell Distribution Width-CV (RDW-CV), Thrombocyte (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Crit (PCT) and Platelet Large Cell Ratio (P-LCR) counts were measured. Lymphocyte DNA damage was assessed by comet assay, additionally, malondialdehyde (MDA) level and catalase (CAT) activity were evaluated. Results: Comet analysis score and P-LCR counts were increased in EMR group compared to Sham group (p<0.05). We observed a decrease in comet analysis score and P-LCR counts after Vit C treatment compared to the finding in EMR group (p<0.05). Conclusions: The results suggest that EMR at the frequency generated by a cell phone causes lymphocyte DNA break and increases P-LCR level. Vit C seems to reduce lymphocyte DNA damage and P-LCR level caused by EMF exposure.

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