Özet:

Aim: COVID-19 has infected quite a lot of people over the past year and has changed our entire lives. The capacitive IgG biosensor, developed in addition to the increasing R&D studies with the COVID-19 pandemic, has been successfully developed by us. Materials and Methods: The capacitive measurement reflects the ease of measurement, only IgG molecules binding to protein-A do not need a secondary marker molecule and direct measurement with rapid measurement. Cystamine, PAMAM and protein-A immobilization was performed on the gold electrode, respectively. Results: It is extremely good to be able to measure within 7 minutes by reducing the measurement time to 400 seconds. The normal values of IgG are in the range of 5.6-18 mg / mL, and the measurability of the increased values after possible COVID-19 infection can be measured in the range of 5-70 mg / mL. The accuracy of the linear measurement, that is, the linear measurement, was calculated as 0.9908, and this value was very close to the number 1, so the linearity of the measurement was evaluated as appropriate. LOD and LOQ values were found to be 1.5 mg / mL and 4.54 mg / mL, respectively. Conclusion: A deviation of less than 5% in the IgG measurement added to the purchased serum samples indicates that the selectivity is high. In this way, a new generation measurement system has been developed.