Özet:

Secondary metabolites of bacteria can be used to control microorganisms. In this study, the antimicrobial activity properties of Bacillus isolates from Apis mellifera and Varroa destructor have been determined. The antimicrobial activities of Bacillus species against some bacteria and pathogenic yeast (Candida albicans) were investigated according to the disc diffusion method. As a result of the research, secondary metabolites of Bacillus isolates used in the study inhibited the development of the tested microorganisms at different rates (1.1-8.4 mm inhibition zone). Two isolates GAP2 (Bacillus subtilis) and GAP9 (Bacillus thuringiensis) showed high antibacterial activity. Most of the metabolites isolated from bacterial isolates were shown to be sensitive to Escherichia coli ATCC2471 and Serratia marcescens ATCC13880 (p<0.05). It was determined that the products obtained from GV6, GV7, GAP7, GAP8, GAP11, GAP13, and GAP15 isolates did not affect any of the bacteria used in the experiments (p<0.05). It is thought that Bacillus strains producing secondary metabolites, especially GAP2 and GAP9 isolates, may have the potential to be used in various applications for saprophytic and pathogenic microbes in medicine, veterinary medicine, agriculture, and the food industry.

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