Özet:

This study is aimed at determining cellular immune response, oxidative stress and fire process in cat infected with feline calicivirus (FCV). In the study, 20 cats infected with FCV and 10 clinically healthy cats were used. In the study, the serum samples collected from all cats, using cat-specific ELISA test kit, determined the levels of adenosine deaminase 1 (ADA-1), paraxonas 1 (PON-1), C-reactive protein (CRP) and serum amyloid A (SAA). The analysis found that the serum ADA-1, SAA and CRP levels of cats infected with FCV were statistically significantly higher than the control groups. In addition, the levels of PON-1 in infected cats are significantly lower than in the control group (p<0,001). In this study, high-level negative correlations (r=-0,73; p<0,001) between ADA-1 and PON-1 were determined, while between other parameters, medium-level correlations were determined. The data obtained in infected cats with FCV shows an increase in the level of ADA-1 active cell response, a decline in the level of PON-1 develops oxidative stress, and an increase in the level of SAA and CRP shows an increase in the level of acute phase response in these cats. As a result, this study has found that in the determination of the state of cellular immune response of ADA-1 in cats infected with FCV, PON-1 can be used as useful biomarker in the determination of oxidative stress and antioxidant capacity, and also in the determination of the acute phase response of SAA and CRP related to the developing fire. Keywords: Biochemistry, Calicivirus, Cat ABSTRACT Abstract: The goals of this study were determination of cell immune responses, oxidative stress, and inflammatory responses in cats infected with FCV. In the study, 20 cats infected with FCV and 10 clinically healthy cats were used. In the study, adenosine deaminase 1 (ADA-1), paraoxonase 1 (PON-1), C reactive protein (CRP) and serum amyloid A (SAA) levels were determined in collected serum samples of all the cats, using cat-specific ELISA test kits. In the present study, serum concentrations of ADA-1, SAA and CRP were significantly higher than those of control group (p< 0,001). Wheras PON-1 concentrations were found to be significantly low compared to that of control group. Furthermore, high negative correlations were obtained between ADA-1 and PON-1 (r=-0,73; p<0,001), while moderate correlations were obtained between other parameters. In this study, elevated serum ADA-1 levels indicate activated cell immune responses and decreased PON-1 levels indicate oxidative stress. Furthermore, increased SAA and CRP levels determine the development of acute phase responses in cats infected with FCV. In conclusion, ADA-1 and PON-1 can be useful biomarkers for detecting activated cell immune responses and oxidative stress in cats infected with FCV, respectively. Furthermore, SAA and CRP can be used to detect acute phase responses in infected cats with FCV. Key words: Biochemistry, Calicivirus, Cat

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