Abstract:

Background: Phototherapy is a non-invasive, well-tolerated, low-cost method that is easilyapplied to neonates with hyperbilirubinemia; however, phototherapy has been reported tocause variations in the levels of oxidative stress markers. Although many studies have beenconducted to assess the relationship between oxidative stress and phototherapy, we could notfind any published study that simultaneously determined paraoxonase (PON) and arylesteraseactivities, lipid hydroperoxide (LOOH) levels, and calculations of total antioxidant capacity(TAC), total oxidant status (TOS) and oxidative stress index (OSI) in newborns withhyperbilirubinemia. This study aimed to evaluate the effects of phototherapy on the oxidativestress panel by determining all of these biomarkers in neonates with hyperbilirubinemia. Materials-Methods: Forty-seven full-term and normal-weight newborns withhyperbilirubinemia requiring phototherapy were enrolled the study. Serum PON andarylesterase activities and TAC, TOS, OSI and LOOH levels were measuredspectrophotometrically. Results: Serum PON and arylesterase activities were increased after phototherapy (p<0,05);whereas, serum TAC, TOS, OSI and LOOH levels were decreased (p<0,05). Serumtriglyceride and uric acid levels were decreased with therapy, while serum LDL-C andalbumin levels were increased (p<0,05). Conclusions: This is the first study to evaluate PON, arylesterase, TAC, TOS and OSI levelsand lipid profile together in neonates receiving phototherapy due to neonatalhiperbilirubinemia. Decrease in TAC, TOS, OSI, LOOH levels and increase in PON and1arylesterase activities after phototherapy can indicate decreasing oxidative stress in neonataljaundice after management with phototherapy.

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