Abstract:

Aim: Platelet to lymphocyte ratio (PLR) predicts worse outcome in cardiovascular disease. However data is limitted about the role of PLR in the diurnal variation of hypertension. In this study we evaluated the relationship between the diurnal variation of hypertension and PLR. Material and Methods: The study included a total of 247 essential hypertensive patients. All patients underwent 24-hour ambulatory blood monitoring. Thereafter hypertensive patients were divided into two groups: 64 dipper patients (30 female, mean age 53.8±12.9 years) and 38 non-dipper patients (18 female, mean age 52.6±12.5years). Complete blood count and biochemistry were measured by standard methods.  PLR was measured by dividing platelet count to lymphocyte count. Results: Non-dipper hypertensives had signifi cantly higher PLR levels than dippers (127.9±32.16 vs 103.4±10.67, p<0.001). There was a negatif correlation between percentage of sistolic and diastolic blood pressure fall and PLR. Conclusion: We demonstrated that PLR, an inexpensive and easily accessible biomarker, is significantly higher in nondipper hypertensives than the dipper hypertensives. 

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