Abstract:

Objective: In this study, we investigated the relationship between the positive core percentage and gleason score with perineural invasion PNI in patients who underwent transrectal ultrasonography TRUSG guided prostate biopsy because of high prostate specific antigen PSA values and abnormal digital rectal examination.Materials and Methods: A total of 1135 patients underwent 10-quadrant TRUSG guide prostate biopsy because of high PSA values and abnormal digital rectal examination in our clinic between 2004-2011. Prostate adenocarcinoma was detected in 274 patients 24.14% . Perineural invasion was demonstrated in 46 16.78% of prostate carcinoma cases. Cases with and without PNI were compared in terms of age, total PSA, prostate volume, PSA density, gleason score, positive core percentage and rectal examination. Patients were divided into 2 groups of total gleason score ≤6 and total gleason score >6, also positive core percentages were divided into 2 groups ≤33% and > 33% and these groups were compared in terms of perineural invasion.Results: The average age was 69.60 ± 6.56 in patients with gleason score ≤6 and 70.68 ± 8.34 in patients with gleason score > 6 p=0.153 . The average PSA level was 12.10 ± 4.57 mg/dl in patients with gleason score ≤ 6 and 13.11 ± 4.53 in patients with gleason score >6 p=0.652. The rate of metastasis on bone scintigraphy was 31.25% in total, 6.6% in with gleason score ≤ 6 and 46. 6% in patients with gleason score >6 p6 p

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