Objective: In this study, our objective was to compare the preoperative clinicopathological and radiographical findings of prostate cancer cases with gleason score 3+4 and 4+3 diagnosed by transrectal ultrasonography TRUSG guided biopsy. Materials and Methods: A total of 1135 patients underwent 10-quadrant TRUSG guide prostate biopsy because of high PSA values or abnormal digital rectal examination in our clinic between 2004-2011. Of those patients who had adenocarcinoma were divided into 2 groups of Gleason score 3+4 Group 1, 56 patients and Gleason score 4+3 Group 2, 48 patients . These two groups were compared in terms of age, total PSA, PSA density, mean prostate size, positive core percentage, a positive core value of 33% or more, mean highest positive core tumor percentage, perineural invasion, rectal examination and tomography findings. Results: Both groups are compared clinical, pathological and in terms of tomographical findings preoperatively. In this comparison, there was no difference in terms of age, total PSA, PSA density; mean prostate volume, positive core percentage, a positive core value of 33% or more, perineural invasion, rectal examination and tomography findings. The mean highest positive core tumor percentage was %69.60 ± 25.31 in group 1 and %86.55 ±17.68 in group 2. The mean highest positive core tumor percentage was significantly higher in the group 2 p
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