Abstract:

Objectives: In this study, it was aimed to determine the adverse drug reactions reported in a university hospital. Materials and Methods: The study is a descriptive cross-sectional study. Data were analyzed retrospectively using 95 “Turkish Pharmacovigilance Center Adverse Reaction Notification Forms” archived in the hospital's Pharmacy Department records between January 01,2018 and December 31,2021. Microsoft Excel PivotTable reports and descriptive statistics were used in the analysis of the data. “The World Health Organization Anatomical Therapeutic Chemical Classification System” was used to classify drugs suspected to cause adverse reactions. Results: In the study, 40.9% of the reported adverse reactions were dermatological symptoms and 18.8% were respiratory distress. It was observed that 41.1% of the patients who developed adverse reactions were diagnosed with acute lymphoblastic leukemia and 10.5% were diagnosed with upper respiratory tract infection. It was determined that 82.1% of the patients developed non-serious adverse reactions and 86.3% of the patients who developed adverse reactions recovered. It was determined that 51.6% of the drugs thought to cause adverse reactions were included in the group of systemic anti-infectives and 27.4% in the group of antineoplastic and immunomodulatory agents. Conclusion: As a result of the study, it was determined that the drug groups that caused the most adverse reactions were systemic antiinfectives, antineoplastics, and immunomodulatory agents, and the most common adverse reactions were dermatological symptoms. It is recommended to identify patients and drugs in the high-risk group for adverse drug reactions, training to employees about adverse reactions, and to carry out advanced studies on the causes of adverse reactions.

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