Özet:

Purpose: The first purpose of this study is to determine the effect of the use of danofloxacin on the oxidative stress biobelider 8-hydroxy-2-deoxiguanozin (8-OHDG). It is also intended to determine the effect of the heart [Troponin I, creatine kinase-MB (CK-MB) isoenzyme, lactate dehydrogenase (LDH), aspartate aminotransferase (AST)], liver [Alkalene phosphate (ALP), alanin aminotransferase (ALT)] and kidney [blood urine nitrogen (BUN), creatine] damage biobelinders on the parameters of the hemogram [Akyuvar number (WBC), alyuvar number (RBC), platelet number, hemoglobin, hematokrit]. Method and method: In the study, 10 sheep were administered in a dose of 6 mg/kg/day (three skin) of danofloxacin for 14 days. 0 is. Blood samples were taken on 1, 3, 5, 7, 9, 11, 13 and 15 days. Serum 8-OHDG, troponin I and CK-MB levels of izoenzim in the ELISA reader, serum LDH, AST, ALT, ALP, creatine and BUN values were determined in the autoanalyzer. The hemogram parameters are measured in the blood cell counting device. Results: While the study did not identify statistical changes at 8-OHDG levels (P>0,05), temporary increases in troponin I, CK-MB izoenzim and AST (P<0,05) were determined. While statistical fluctuations in the BUN value (P<0,05) were observed, declines in the WBC, RBC, hemoglobin and hematocrit values (P<0,05) and temporary rise in the platelet level (P<0,05) were observed. Consequently, it can be stated that the 14-day application of danofloxacin to cows may not cause systemic oxidative stress, and may not cause serious effects on the function of the heart, liver, kidney and bone marrow.

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