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Amaç: Diş hekimliğinde tedavi ve koruma amaçlı doğal ürünlerden köken alan biyolojik aktif bileşiklere artan ilgi her geçen gün devam etmektedir. Bu çalışmanın amacı farklı etken maddelere sahip bitkisel ve doğal içeriklere sahip diş macunlarının antimikrobiyal etkinliğinin değerlendirilmesidir. Gereç ve Yöntem: Çalışmada farklı içeriğe sahip dokuz diş macununun (Fluor/500 ppm, Misvak+propolis+çay ağacı, Ganoderma lucidum ekstresi, himalaya tuzu, misvak özlü, Xlylitol, Aleo vera özlü, Ev yapımı) Streptococcus mutans ATCC 25175, Lactobacillus acidophilus ATCC 4356 ve Candida albicans ATCC 10231 kökenlerine karşı antimikrobiyal etkinliği agar difüzyon tekniği ile test edildi. İstatistiksel analizler Mann Whitney U testi ile değerlendirildi. Bulgular: Test edilen diş macunlarının S.mutans’a karşı antimikrobiyal etkinlikleri incelendiğinde aloe vera özlü diş macununun, test edilen diğer diş macunlarına kıyasla antimikrobiyal etkinliğinin anlamlı olarak daha yüksek olduğu tespit edildi (p<0,05). L. acidophilus’a karşı etkinlikleri incelendiği zaman ise, aleo vera özlü ve ev yapımı diş macunlarının antimikrobiyal etkinliklerinin diğer diş macunlarından istatistiksel olarak anlamlı derecede yüksek olduğu gözlemlenmiştir (p<0,05). Sonuç: Çalışmamızda incelenen alternatif etken maddeler ile üretilen diş macunlarının in vitro koşullarda antimikrobiyal etkiler gösterebileceği gözlenmiştir. In vitro çalışmaları yapılan diş macunların aktif bileşenlerinin ağız içerisinde, pH üzerine etkisi, tükürükte seyrelmesi sonucu oluşacak antimikrobiyal etkinliğinin değerlendirilmesi adına klinik çalışmalara ihtiyaç duyulmaktadır. Anahtar kelimeler: diş macunu, fluor, bitkisel diş macunu Investigation of antimicrobial activity of herbal toothpastes with different active substances ABSTRACT Objective: There is increasing interest in biologically active compounds originating from natural products for treatment and protection in dentistry. The aim of this study was to evaluate the antimicrobial efficacy of toothpastes with herbal and natural ingredients with different active ingredients. Material and Methods: The antimicrobial activity of nine toothpaste (Fluor / 500 ppm, Miswak + propolis + tea tree, Ganoderma lucidum extract, himalaya salt, miswak extract, Xlylitol, Aleo vera extract, Homemade) were tested by agar diffusion technique against the Streptococcus mutans ATCC 25175, Lactobacillus acidophilus ATCC 4356 and Candida albicans ATCC 10231. Mann Whitney U test was used for statistical analysis. Results: The antimicrobial activity of the tested toothpastes against S.mutans showed that the aloe vera toothpaste had significantly higher antimicrobial efficacy than all toothpastes tested (p <0.05). The antimicrobial activities of aleo vera extract and home-made toothpastes against the L.acidophilus were significantly higher than other toothpastes (p <0.05). Conclusion: In our study, it has been observed that some toothpastes produced with alternative active substances may have antimicrobial effects in in vitro conditions. Clinical studies are needed to evaluate the antibacterial efficacy of the active ingredients of the tooth pastes on the pH, saliva dilution in the mouth. Keywords: tooth paste, fluoride, herbal toothpaste
Purpose: The increasing interest in biologically active compounds that come from natural products for treatment and protection in dental medicine continues every day. The aim of this study is to evaluate the antimicrobial effectiveness of toothpaste with vegetable and natural contents with different active substances. In the study, the anti-microbial effectiveness of nine toothpaste with different content (Fluor/500 ppm, Misvak+propolis+ tea tree, Ganoderma lucidum extract, Himalaya salt, Misvak extract, Xlylitol, Aleo vera extract, Home made) against the origins of Streptococcus mutans ATCC 25175, Lactobacillus acidophilus ATCC 4356 and Candida albicans ATCC 10231 was tested by the agar diffusion technique. The statistical analysis was evaluated by the Mann Whitney U test. Tested toothpaste S. When an antimicrobial effect against mutans was studied, the aloe vera extract toothpaste was found to have a significantly higher antimicrobial effect than the other toothpaste tested (p<0,05). When the effects against L. acidophilus were studied, the antimicrobial effects of aleo vera extract and home-made toothpaste were statistically significantly higher than other toothpaste (p<0,05). The result: The study has observed that toothpaste produced with alternative active substances in vitro conditions may have antimicrobial effects. In vitro studies requires clinical trials in order to evaluate the anti-microbial effectiveness of the active components of toothpaste in the mouth, the effect on pH, the result of sputum. Research of antimicrobial activity of herbal toothpastes with different active substances ABSTRACT Objective: There is increasing interest in biologically active compounds originating from natural products for treatment and protection in dentistry. The aim of this study was to evaluate the antimicrobial effectiveness of toothpastes with herbal and natural ingredients with different active ingredients. Material and Methods: The antimicrobial activity of nine toothpaste (Fluor / 500 ppm, Miswak + propolis + tea tree, Ganoderma lucidum extract, himalaya salt, miswak extract, Xlylitol, Aleo vera extract, Homemade) were tested by agar diffusion technique against the Streptococcus mutans ATCC 25175, Lactobacillus acidophilus ATCC 4356 and Candida albicans ATCC 10231. Mann Whitney U test was used for statistical analysis. Results: The antimicrobial activity of the tested toothpastes against S.mutans showed that the aloe vera toothpaste had significantly higher antimicrobial effectiveness than all toothpastes tested (p <0.05). The antimicrobial activities of aleo vera extract and home-made toothpastes against the L.acidophilus were significantly higher than other toothpastes (p <0.05). Conclusion: In our study, it has been observed that some toothpaste produced with alternative active substances may have antimicrobial effects in in vitro conditions. Clinical studies are needed to evaluate the antibacterial effectiveness of the active ingredients of the toothpaste on the pH, saliva dilution in the mouth. Keywords: tooth paste, fluoride, herbal toothpaste
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