Özet:

This study aimed to investigate the effect of vancomycin on sperm motility and testicular inflammation in male rats. In the study, 12 adult Sprague Dawley rats were used. They were divided into 2 equal groups. First group (n = 6) was called as control group. Control group received physiological saline via intraperitoneal injection. Second group was called as vancomycin group and vancomycin group received vancomycin at the dose of 200 mg/kg via intraperitoneal injection for consecutive 7 days. At the end of study, the rats were sacrificed under sevoflurane anesthesia. Testes and cauda epididymis were collected. Mean testes weight, mean cauda epididymis weight, and sperm motility were evaluated. Also, tumor necrosis factor-alpha and nuclear factor kappa B levels were evaluated in testis tissues. According to our results, vancomycin treatment significantly decreased sperm motility while did not change mean testis weight and mean cauda epididymis weight when compared to control group. Besides, tumor necrosis factor-alpha and nuclear factor kappa B levels were significantly higher in vancomycin group than in the control group. In conclusion, vancomycin treatment (200 mg/kg BW, consecutive 7 days) decreases sperm motility significantly and increases the levels of testicular inflammation biomarkers (tumor necrosis factor-alpha and nuclear factor kappa B). Further studies are needed for protection from the side effects of vancomycin in male reproductive system.