Özet:

Objectives: We aimed to compare the effect of hepatitis C virus (HCV)-RNA, HCV-genotype 1b, and anti-HCV positivity on laboratory parameters in our study. Materials and Methods: HCV-RNA and anti-HCV tests were analyzed from 500 patients and the HCV genotyping test was applied to 100 patients between January 2018 and September 2020. Hemoglobin, white blood cell, platelet (PLT), mean platelet volume (MPV), platelet distribution width, the volume of platelet of total blood volume-plateletcrit, mean corpuscular volume, red cell distribution width, alpha-fetoprotein (AFP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), albumin, prothrombin time, partial thromboplastin time (PTT), International Normalized Ratio values were analyzed simultaneously. Results Age, AFP levels, AST, ALT, GGT, ALP, PTT, and MPV values were detected to be significantly higher in HCV-RNA positive patients than in HCV-RNA negative patients. Anti-HCV titer, PLT, and albumin values were found to be lower in HCV-RNA positive patients compared with HCV-RNA negative patients. HCV-RNA, AST, ALP, and GGT values were higher in anti-HCV positive patients compared to anti-HCV negative patients. Albumin values were lower in anti-HCV positive patients than in anti-HCV negative patients. The average age of patients with HCV-genotype 1b was determined to be higher than that of patients with non-HCV-genotype 1b. Conclusion: HCV-RNA is the most important specific biomarker that affects other non-specific parameters used to evaluate HCV infection. The detection of genotype 1b in patients with HCV infection may be guiding in the treatment of older patients than non-genotype 1b.

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