Aim: Mean platelet volume (MPV) is a marker of platelet activity that has been found to be lower in people with colon cancer than in healthy people. In order to forecast the probability of colon cancer development in colon polyps, we looked at the predictive values of MPV, platelet distribution width (PDW), platelet count/MPV (Plt/MPV) and monocyte (Mo) count. Method: This was a retrospective study. The study comprised colonoscopy procedures performed at a single hospital between 02.01.2019 and 05.05.2021. Colon polyps detected during colonoscopy in 425 patients were included. Colon polyps that underwent polypectomy were separated into two groups based on histopathological analysis into benign and malignant. Standard complete blood count parameters were assessed in both groups and Plt/MPV, Plt/PDW, neutrophil/lymphocyte ratio (NLR), and Mo/lymphocyte ratio (MLR) values were calculated. Results: The total number of polyps removed was 754. Haemoglobin and red cell distribution width values were statistically lower in the adenocarcinoma group (p<0.001 for both). When the values of NLR, MLR, Plt/PDW, and Plt/MPV were compared, the Plt/PDW and MLR were significantly higher in the adenocarcinoma group (p=0.036 and p=0.004, respectively). Conclusion: The Mo count and MLR and Plt/PDW ratios were useful for detecting malignancies that may arise from colon polyps in this retrospective cohort. Polyps detected in patients with a high Mo count or MLR or Plt/PDW ratio measured before the procedure may be associated with a higher risk of cancer but these results should be confirmed in larger prospective studies.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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