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Kronik Obstrüktif Akciğer Hastalığı (KOAH) sistemik inflamasyon ile seyreden bir hastalıktır ve sistemik inflamasyon KOAH’ta morbidite ve mortalitenin ana nedenidir. OSAS ve KOAH birlikteliği yani Overlap Sendromu (OS) toplumda % 1 sıklığında görülmektedir. Bu iki hastalığın birlikteliğinde sistemik inflamasyon şiddeti daha da artmaktadır. Bu nedenle de OS’lı hastalarda morbidite ve mortalite daha fazla oranda görülmektedir. Bu çalışmanın amacı KOAH ve OS’li hastalarda kardiyopulmoner egzersiz testleri arasında anlamlı farklılık olup olmadığını saptamaktı. Çalışmamızda 18 hastaya Kardiyopulmoner Egzersiz Testi (KPET) yapılmıştır. Test yapılan hastaların 12’si KOAH’lı ve 6’sı OS’lu idi. Çalışmaya alınan hastalara Vmax Encore, USA cihazı kullanılarak semptom sınırlı incremental KPET uygulandı. KPET sonucu maksimum oksijen tüketimi (VO2max ml/kg/min) KOAH’lı grupta 15,5 ±6,4, OS’lı grupta 12,4±6 saptandı. Bu açıdan anlamlı fark yoktu (P>0,05). Karbondioksit üretimi (VCO2 L/min) açısıdan da iki grup arasında anlamlı fark saptanmadı (p>0,05). Maksimum iş kapasitesi (work-watt) KOAH’lı grupta 59,2±29, OS’lı grupta 45,8±19 saptadı. Bu değerler arasında da anlamlı fark saptanmadı (p>0,05). Hastaların maksimum kalp hızı dakikada KOAH’lı grupta 120±21 ,OS’lı grupta 116±18 olarak saptandı. Oksijen pulse değeri (ml/atım) ve maksimum kalp hızı açısından İki grup karşılaştırmasında anlamlı fark yoktu (p>0,05) .Maksimum ventilasyon oranı (VEmax-L/dk) KOAH’lı grupta 43±13, OS’lı grupta 36,6±9,2 olarak saptadı. İki grup arasında anlamı fark saptanmadı (p>0,05). Endtidal CO2 değeri ve Endtidal O2 değeri açısında KOAH’lı ve OS’lı grup karşılaştırıldığında anlamlı fark saptanmadı (p >0,05) . Solunum katsayısı yani RQ oranı KOAH’lı grupta 1,1 ±0,4 iken OS’lı grupta 1,1±0,4 saptandı. İki grupta anlamlı fark yoktu. Anaerobik treeshot (AT) değeri KOAH’lı ve OS’lı grupta benzerdi. Bu değerler arasında da istatistiksel anlamlı fark saptanmadı (p>0,05). Sonuç olarak değerlendirildiğinde KOAH ve OS’lu hastalarda KPET değerlerini normal popülasyona göre düşük saptamakla birlikte iki hastalık arasında anlamlı farklılık saptamadık.
Chronic Obstructive Lung Disease (KOAH) is a disease seen with systemic inflammation and systemic inflammation is the main cause of morbidity and mortality in KOAH. OSAS and KOAH association (Overlap syndrome) are 1 percent common in society. In the combination of these two diseases, the severity of the systemic inflammation increases further. Therefore, morbidity and mortality are more common in patients with OS. The aim of this study was to determine whether there is a significant difference between cardiopulmonary exercise tests in KOAH and OS patients. In our study, 18 patients were tested for cardiopulmonary exercise (KPET). 12 of the patients tested were with KOAH and 6 with OS. Patients in the study were applied Vmax Encore, USA device with symptom-limited incremental KPET. The KPET resulted in maximum oxygen consumption (VO2max ml/kg/min) at 15.5 ± 6.4 in the KOAH group, 12.4 ± 6 in the OS group. There was no meaningful difference in this regard (P>0,05). There was no significant difference between the two groups in terms of carbon dioxide production (VCO2 L/min) (p>0,05). The maximum work capacity (work-watt) was 59.2±29 in the KOAH group, 45.8±19 in the OS group. There is no significant difference between these values (p>0,05). The maximum heart rate of patients was 120±21 per minute in the KOAH group and 116±18 in the OS group. There was no significant difference in the comparison of the two groups in terms of the oxygen pulse value (ml/s) and maximum heart rate (p>0,05) . The maximum ventilation rate (VEmax-L/min) was 43±13 in the KOAH group, 36,6±9,2 in the OS group. There is no difference between the two groups (p>0,05). There was no significant difference in comparison of CO2 and CO2 in terms of CO2 and CO2 in terms of CO2 and CO2 in terms of CO2 in terms of CO2 and CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2 in terms of CO2. The respiratory ratio, RQ ratio, was 1.1 ± 0.4 in the KOAH group, while 1.1 ± 0.4 in the OS group. There was no significant difference between the two groups. The Anaerobic treeshot (AT) value was similar in the group with KOAH and OS. There is no statistically significant difference between these values (p>0,05). When assessed as a result, we did not find a significant difference between the two diseases, although the KPET values were low compared to the normal population in patients with KOAH and OS.
Chronic Obstructive Pulmonary Disease (COPD) is a disease that progresses through inflammation and the main reason for morbidity in COPD is this inflammation. The rate of appearance of OS (Overlap Syndrome) and COPD together is %1 in the general public. Systemic inflammation increases the severity even more when the two diseases appear together. This is why the morbidity and mortality rates are higher with patients diagnosed with OS. The purpose of this study is to find out whether there is a significant difference between the cardiopulmonary exercise test results for patients with the COPD and Overlap Syndrome (OS). 18 patients were subjected to Cardiopulmonary Exercise Tests (CPET) within the scope of the study. 12 of the patients were diagnosed with COPD and 6 of them with OS. A symptom-limited incremental CPET was performed using a Vmax Encore, USA device. Informed consent was obtained from all subjects. The results of the CPET revealed that the maximum oxygen consumption (VO2max ml/kg/min) in the group of patients with COPD was 15,5 ±6,4, and 12,4±6 in the group with OS. There was no significant difference in that sense (p>0,05). There was also no significant difference in carbon dioxide outturn between the two groups (VCO2 L/min) (p>0,05). The maximum work-watt in the group of patients with COPD was 59,2±29, and 45,8±19 in the group with OS. There also was no significant difference between these results (p>0,05). The maximum throb of the group of patients diagnosed with COPD was 120±21, and 116±18 in the group with OS. The comparison of Oxygen pulse value (ml/Pulse) and maximum throb did not show any significant difference either (p>0,05). The maximum ventilation rate (VEmax-L/min) in the group of patients with COPD was 43±13, and 36,6±9,2 in the group with OS. No significant difference was found between the two groups. (p>0,05). End-tidal CO2 values and end-tidal O2 values did not show any significant difference either. When compared (p >0,05). The respiratory quotient RQ in the group with COPD was 1,1 ±0,4 whereas in the group with OS the value was 1,1±0,4. No significant difference. The anaerobic thresold (AT) values in both groups were similar. No statistically significant difference was found between these two values either. (p>0,05). Although the CPET values of patients diagnosed with COPD and OSD were below the general population, there were no significant differences between the two diseases.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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