Özet:

Abstract Objective: This study aims to compare the effectiveness of non-pharmacological combined treatment methods used in Fibromyalgia syndrome (FMS) treatment by evaluating serum β -Endorphine, pain, depression, sleep quality and functional status. Methods: The study included 60 patients diagnosed with FMS and 30 healthy female volunteers. The patients with FMS were divided into two equal groups of 30 subject. The first group of patients received physical therapy and balneotherapy, while the second group received physical therapy, balneotherapy and aerobic exercise program. FMS patients evaluated before and after treatment, by Visual Analogue Scale for Pain (VAS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Scale (BDI) and Pittsburgh Sleep Quality Index (PSQI) questionnaires. Serum β-Endorphin levels were measured once in the healthy control group and twice before and after treatment in FMS patients. Results: The β-Endorfin level was lower in both FMS groups than the control group and this was statistically significant (p <0.001). Post-treatment β-Endorphin levels were high in the both FMS group and this difference was statistically significant (p <0.001). However, in the FMS group receiving physical therapy, balneotherapy and aerobic exercise, post-treatment β-Endorphin levels were higher than the FMS group receiving physical therapy and balneotherapy, and this was statistically significant (p <0.001). In both groups, we found that the scores of FIQ, VAS, BDI and PSQI after treatment were decreased compared to pretreatment and this was statistically significant (p <0.001). Conclusion: The serum β-Endorphin levels were found to be lower in the FMS patients. Aerobic exercise and balneotherapy are effective methods in the treatment of FMS. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FMS.

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