Abstract:

Aim: This study aimed to investigate the predictability of mortality based on biomarkers measured using complete blood count in geriatric patients who underwent proximal femoral nail fixation for intertrochanteric femur fractures. Methods: We included in this retrospective study 247 patients who had undergone proximal femoral nailing due to osteoporotic intertrochanteric femur fracture. The patients were divided into two groups according to 1-year mortality outcome: group A, survivors (n=162), and group B, deceased patients (n=85). Preoperative demographic information, the number of days until surgery, C-reactive protein (CRP) level, hemoglobin level, platelet-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammatory index (SII) were recorded. Results: No statistically significant differences were found between the groups in terms of sex, type of anesthesia, leukocyte count, and neutrophil level (p>0.05), but statistically significant differences were found in age, number of days until surgery, CRP level, hemoglobin level, lymphocyte count, and platelet count (p<0.05). The NLR significantly increased in the group with mortality (p<0.05), while SII and PLR yielded similar results in both groups (p>0.05). In the receiver-operating characteristic curve analysis, the NLR, SII, and PLR areas under the curve for mortality were 0.598, 0.549, and 0.569, respectively. Conclusion: None of the biomarkers investigated in this study showed an ability to distinguish patients with higher mortality risks. Therefore, these biomarkers may be recommended not as predictive of mortality but as supportive parameters for determining patients’ overall clinical statuses.

Keywords: