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Abstract Object: In this study we aimed to investigate maspin expressions by immunhistochemistry in bladder urothelial carsinomas and to examine the relationship with clinicopathological parameters. Introduction: Maspin is a member of the serpin (serine protease inhibitor) family and has been shown to be a suppressor of tumor growth and an inhibitor of angiogenesis as well as metastasis in several types of tumors. The most important factors in determining the prognosis in the urinary bladder tumors are the histological grade and stages.  Material and Methods: The samples were obtained from the 67 cases underwent transurethral resection-bladder(TUR-B) between the 2005-2011, which diagnosed with urothelial carcinomas at Gaziantep University School of Medicine Department of Pathology. The cases according to the WHO / ISUP 2004 grading system were; 3 PUNLMP, 25 LGUC, 39 HGUC. Results:They are distributed as 35 pTa, 17 pT1, 12 pT2, 1 pT3, 2 pT4 according to pathologic staging. Histologic grading was significantly related with invasion and pT staging. As the histological grade was increased, invasion and pT staging were increased significantly (p=0,001). In this study, 57 (85.1%) tumoral cases were positive for maspin. According to maspin expression level, the cases were classified as 4 (%6) 1+, 26 (%38.8) 2+, 27 (%40.3) 3+. Although it was not statistically significant, maspin positivity was higher in noninvasive and low-grade tumors. Considering maspin expression level, it was significantly associated with histologic grading and pT staging (p=0,009, p=0.020). Maspin expression score was significantly negatively correlated with pT staging and histologic grading (r=-0.283, p=0.020) (r=-0.316, p=0.009). There was no correlation between the maspin expression and tumor recurrence and tumorrelated death (p = 0,933,p = 0,208).  Conclusion:According to our results, maspin expression seems to be related with lower histologic grade and stage in bladder urothelial carsinomas. Our findings suggested that the evaluation of maspin expression in bladder tumors is useful prognostic marker for predicting the tumor behavior.

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