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This mini review and systematic meta-analysis aimed to investigate some biomarkers that have been investigated in the diagnosis or prognosis of colorectal carcinoma. Analyzes show that carcinoembryonic antigen (CEA) has moderate sensitivity and high specificity in the diagnosis of colorectal carcinoma, but it is insufficient to detect colorectal cancer and can be used to determine prognosis. Carbohydrate Antigen 19-9 (CA19-9) alone cannot be used for colorectal carcinoma screening, diagnosis, prognosis or detection of relapses, and it can be used when used in conjunction with other markers. It has been shown that Cancer Antigen 242 (CA242) can be used in combination with different tumor markers such as CEA and / or CA19-9 in the diagnosis and prognosis of colorectal carcinoma. C-reactive protein (CRP) is a specific marker for inflammation, it can be used to determine the risk of developing colorectal carcinoma, to diagnose and to understand prognosis, but it is not a specific marker of colorectal carcinoma. Vascular Endothelial Growth Factor (VEGF) is associated with colorectal carcinoma and VEGF can be used as a marker in the diagnosis and prognosis of these cases. It has been shown that microRNAs can be used for colorectal carcinoma screening, diagnosis and prognosis. Other markers include Cancer Antigen 50 (CA-50), Insulin Like Growth Factor Binding Protein 3 (IGFBP-3), Insulin Like Growth Factor-1 (IGF-1), Cancer Antigen 72-4 (CA72-4). Tumor Related Glycoprotein-72 (TAG-72), P53, Cancer Antigen 125 (CA125), c-erbB-2 protein, Tissue Metalloproteinase Inhibitor-1 (TIMP-1) and Pyruvate Kinase Isoenzyme M2 (M2-PK) have been shown to be limited in colorectal carcinoma. A highly reliable biomarker for screening, diagnosis, follow-up and prognosis of colorectal carcinomas has not yet been established. However, the search for markers is of great benefit to the clinician and the patient, despite varying sensitivity and specificity rates. In particular, the combined use of some markers has been shown to provide significant benefit in these cases.
This mini review and systematic meta-analysis aimed at investigating some biomarkers that have been investigated in the diagnosis or prognosis of colorectal carcinoma. Analysis shows that carcinoembryonic antigen (CEA) has moderate sensitivity and high specificity in the diagnosis of colorectal carcinoma, but it is insufficient to detect colorectal cancer and can be used to determine the prognosis. Carbohydrate Antigen 19-9 (CA19-9) alone cannot be used for colorectal carcinoma screening, diagnosis, prognosis or detection of relapses, and it can be used when used in conjunction with other markers. It has been shown that Cancer Antigen 242 (CA242) can be used in combination with different tumor markers such as CEA and/or CA19-9 in the diagnosis and prognosis of colorectal carcinoma. C-reactive protein (CRP) is a specific marker for inflammation, it can be used to determine the risk of developing colorectal carcinoma, to diagnose and to understand the prognosis, but it is not a specific marker of colorectal carcinoma. Vascular Endothelial Growth Factor (VEGF) is associated with colorectal carcinoma and VEGF can be used as a marker in the diagnosis and prognosis of these cases. It has been shown that microRNAs can be used for colorectal carcinoma screening, diagnosis and prognosis. Other markers include Cancer Antigen 50 (CA-50), Insulin Like Growth Factor Binding Protein 3 (IGFBP-3), Insulin Like Growth Factor-1 (IGF-1), Cancer Antigen 72-4 (CA72-4). Tumor Related Glycoprotein-72 (TAG-72), P53, Cancer Antigen 125 (CA125), c-erbB-2 protein, Tissue Metalloproteinase Inhibitor-1 (TIMP-1) and Pyruvate Kinase Isoenzyme M2 (M2-PK) have been shown to be limited in colorectal carcinoma. A highly reliable biomarker for screening, diagnosis, follow-up and prognosis of colorectal carcinomas has not yet been established. However, the search for markers is of great benefit to the clinic and the patient, despite varying sensitivity and specificity rates. In particular, the combined use of some markers has been shown to provide significant benefit in these cases.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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