Abstract:

Purpose: This study aims to study the clinical characteristics of children who are diagnosed with growth hormone deficiency (BH) and are treated with BH. Tools and Methods: Oxyological, biochemical, radiological findings and therapeutic responses of children who received BH treatment between 01.06.2013 and 31.12.2018 were reviewed backward in a third stage health center. It compared the groups of patients with isolated growth hormone deficiency (IBHE) and panhipophytoticism. The findings: 70 of the 118 male patients in the study, 78 (66.3%) had HIV/AIDS, 14 (11.9%) had bioinactive BH syndrome, 9 (7.6%) panhipopythitarism, 6 (5.1%) BH neurosecretural dysfunction, 6 (5.1%) Turner syndrome, 5 (4.2%) had BH treatment for non-indicated causes. In comparison with children with IBHE and panhipopithearism, there was no difference between the groups in terms of gender distribution, diagnosed age and application oxyological characteristics. In children with panhipopituitarism, the serum IGF-1 SDS, IGFBP-3 SDS, TSH levels and clonidine tests found a lower height BH response (rendered to p=0.026, p=0.002, p=0.009 and p=0.005). The prolongation rate was significantly increased in the first 2 years in the panhipophytotic group with BH therapy (1 year p<0.001, 2 year p=0.005). The patient’s 1 year expansion rate with the diagnosed age, the diagnosed calendar age bone age difference, the BH warning test answers and the correlation between the IGFBP-3 SDS. The result: Patients with panhipophytoticism have observed that the laboratory findings in favour of the BH deficiency in Nazaran application to those with IBH were clearer and in monitoring the BH treatment answers were better.

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