Abstract:

Objective: Malignant Pleural Mesothelioma (MPM) generally associated with asbestos exposure is a tumor with poor prognosis. Modified Glasgow Prognostic Score (GPS) which may be a prognostic parameter in patients with MPM is a designed based score including increased C-reactive protein (CRP) levels and decreased albumin .In this study we aimed to investigate the effect of GPS score on the prognosis of MPM and the role of other potential factors. Methods: In this retrospective planned study 140 histological diagnosed MPM patients were included. Results: Mean age of 140 MPM patients were 52.92 years (83 male and 57 female). A total of 91 patients had environmental asbestos exposure and exposure time was the 31 years. Symptoms of the patients started approximately 4.8 months before the application. The most frequently seen symptoms were in 125 patients dyspnea, in 94 patients chest pain and in 22 patients weight loss. GPS score of the patients were as follows; 64 patients two, 14 patients one, 22 patients zero. Of the patients, 112 died and 28 were alive. Mean survival time was 14 months. Patients with GPS score 2 lived for 10 months, GPS score 1 lived for 15 and GPS score 0 lived for 18 months. This difference was statistically significant. Furthermore, the male sex and age older than 65 years were found as poor prognostic parameters on the survival. Conclusion: A simple and inexpensive parameter able to be used to estimate the prognosis of MPM patients could not be developed .GPS score increases in inflammatory conditions. GPS is a simple and inexpensive parameter that can be used for detecting the severity of patients with MPM.

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