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Sentınel lymph node in the first lymph node that thyroid nodule drains. Our aim was to detect if isosulfan injection was effective in detecting solitary and dominant non-functional thyroid nodules. In this prospective study, in 25 cases who were operated inTrakya Univercity medical faculty department of general surgery and who have solitary and non-functional thyroid nodule and who do not have palpable lymphadenopathy, after the intra operative intranodular injection of the isosulfan blue-dye, the frozen section and haematoxylin eosin stained sections investigations of sentinel lymph nodes which were stained together with the thyroid nodule were done and the clinical significance of the method was evaluated. In 48% of the cases, sentinel lymph node was stained. Most of the lymph nodes were at the ipsilateral side of the nodule in thyroid and located paratracheal. In 4 of the 5 cases, in which malignancy was determined in thyroid nodule, sentinel lymph node was stained and only in one case, lymphatic metastases was indicated.In cases, in which sentinel lymph nodes were stained with the isosulfan blue-dye, there was no significant difference between the frozen section and haematoxylin eosin stained sections results of the lymph nodes. It has been reported that, in proportion to thyroid nodule, in the frozen section investigation, the sensitivity and the spectifity values were very high.(sensitivity, specificity 100%). It has been reported that, immunohistochemistry dyeing, which is applied to reveal micrometastases, does not have any superiority than the haematoxylin eosin dyeing.The evaluation of the thyroid nodule investigation together with the sentinel lymph node frozen section investigation and the identification of the malignancy, would provide the chance of a more curative operation for the surgeon.We think that, with an increase in the number of the cases and in the surgical experience, with the including of the lymphoscintigraphy together with the gamma probe, in higher numbers of sentinel lymph nodes can be displayed.
Lymph nodes in the first lymph nodes that thyroid nodule drains. Our aim was to detect if isosulfan injection was effective in detecting solitary and dominant non-functional thyroid nodules. In this prospective study, in 25 cases who were operated inTrakya University medical faculty department of general surgery and who have solitary and non-functional thyroid nodule and who do not have palpable lymphadenopathy, after the intra-operative intranodular injection of the isosulfan blue-dye, the frozen section and haematoxylin eosin stained sections investigations of sentinel lymph nodes which were stained together with the thyroid nodule were done and the clinical meaning of the method was evaluated. In 48% of the cases, the sentinel lymph nod was stained. Most of the lymph nodes were at the ipsilateral side of the nodule in the thyroid and located paratracheal. In 4 of the 5 cases, in which malignity was determined in the thyroid nodule, the sentinel lymph nod was stained and only in one case, lymphatic metastases was indicated.In cases, in which the sentinel lymph nodes were stained with the isosulfan blue-dye, there was no significant difference between the frozen section and haematoxylin eosin stained sections results of the lymph nodes. It has been
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