Abstract:

Aims: The relationships between C-reactive protein (CRP), the systemic immune inflammation index (SII), and inflammatory markers derived from the hemogram are unknown in children with acute otitis media (AOM) infections. This study investigated the correlations between CRP, SII, and inflammatory markers in pediatric patients with AOM. Methods: This retrospective study included pediatric cases diagnosed with AOM at the Pediatric Emergency Service of the Gülhane Training and Research Hospital between November 2016 and January 2019. The SII (neutrophil x platelet/lymphocyte), neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), lymphocyte-to-monocyte ratio (LMR), plateletto-lymphocyte ratio (PLR), mean platelet volume (MPV)-to-lymphocyte ratio (MPVLR), and lymphocyte-to-CRP ratio (LCR) values of the patients were analyzed. Correlations between CRP level, hemogram parameters and inflammatory markers were studied. Results: Among the 252 cases, the median age was 2.0 (1-5) years, and 140 (55.6%) were male. There were no significant differences between the boys and the girls in terms of age, CRP, hemogram parameters, or related inflammatory markers (p>0.05). Significant correlations were found between CRP and SII (r=0.375, p=0.001), leukocyte count (r=0.300, p=0.001), neutrophil count (r=0.459, p=0.001), lymphocyte count (r=-0.174, p=0.006), NLR (r=0.407, p=0.001), NMR (r=0.257, p=0.001), LMR (r=-0.393, p=0.001), PLR (r=0.137, p=0.03), MPVLR (r=0.173, p=0.006), and LCR (r=-0.881, p=0.001). There were no correlations between CRP or SII and PLT or MPV. Conclusions: High CRP, SII, and inflammatory markers calculated using the routine hemogram parameters correlate in pediatric patients with AOM.

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